Phone: 49.761.27035590 Fax: 49.761.27063930 E-mail: note: C. Protein scaffolds are members of the signaling cascade downstream of cell surface receptors. Huber, Uniklinikum Freiburg, Zentrale Klinische Forschung, Breisacherstrasse 66,79106 Freiburg, Germany. Phone: 6462 Fax: 6467 E-mail: Or to: Tobias B. Protein engineers use the term to refer to a domain or small protein that is the object of mutation intended to introduce or refine a property, while retaining. Frangakis, Cluster of Excellence Macromolecular Complexes, Johann Wolfgang Goethe University Frankfurt, Institute of Biophysics, Max-von-Laue-Str. Scaffold, anchoring, and adaptor proteins coordinate the assembly and localization of signaling complexes providing efficiency and specificity in signal.
The best-known example of scaffold protein is MEKK1 protein. A scaffold ideally permits the attachment, differentiation, and maturation of cells in a specified manner, mimicking the 3D cytoarchitecture of meat while. After binding, the scaffold protein tethers these multiple proteins into complexes. Louis, Missouri, USA.ġ6Division of Nephrology and Katz Family Drug Discovery Center, University of Miami Miller School of Medicine, Miami, Florida, USA.ġ7FRIAS, Freiburg Institute for Advanced Studies and ZBSA, Center for Biological System Analysis, Albert-Ludwigs-University of Freiburg, Germany.Īddress correspondence to: Achilleas S. Scaffold protein is a large protein that interacts with multiple proteins of a signalling pathway in order to regulate signal transduction. 1Department of Medicine, Division of Nephrology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ĢBuchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, Frankfurt, Germany.ģSpemann Graduate School of Biology and Medicine,ĥBIOSS Center for Biological Signalling Studies, Albert-Ludwigs University of Freiburg, Freiburg, Germany.ĦInstitute of Anatomy, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ħKI/AZ Integrated Cardio-Metabolic Center (ICMC), Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden.ĨInstitute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ġ0German Cancer Research Center, Heidelberg, Germany.ġ1Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ġ2Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.ġ3Institute of Virology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.ġ4Department of Pathology, University of Vienna, Vienna, Austria.ġ5Renal Division, Washington University, St.
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